“We successfully monitor cardiac surgery patients’ coagulation status using the iCoagLab technology,” concluded the authors. The iCoagLab and TEG values for MA (r=.71 P <.001) and α-angle (r=.68 P <.0001) were also moderately correlated. In all the cases, addition of protamine significantly reversed effects of heparin (2 USP/mL), shortening the ACTs measured by the iCoagLab, TEG, and i-STAT kaolin ACT and restoring α-angle and MA values measured by the iCoagLab and TEG back to baseline values.Īmong the 6 timepoint samples from the patients undergoing cardiac surgery, the iCoagLab ACT was strongly correlated with the TEG ACT (r=.87 P <.0001) and moderately correlated with the Hepcon ACT (r=.76 P <.0001). At high heparin doses, like TEG, the iCoagLab device measured decreasing MA ( P <.01). In the device performance testing, addition of heparin significantly prolonged the ACT measured by iCoagLab, and the iCoaglab ACTs were strongly correlated with those of TEG (r=.91 P <.0001) and i-STAT ACT (r=.78 P <.0001). Samples were assessed at 6 timepoints during surgery: at baseline, after heparin administration, before CPB, after CPB, before protamine administration, and after protamine reversal. Clinical testing during cardiac surgery was conducted using whole blood samples from 30 patients. To test device performance, the team used whole blood samples from 18 healthy volunteers the samples were spiked with heparin (1-5 USP/mL) and subsequently with protamine (30-90 µg/mL) to neutralize heparin. Of note, according to the authors, the hand-held iCoagLab device requires only 25µL of whole blood and produces results within minutes. ![]() ![]() These parameters were also measured using conventional thromboelastography (TEG), i-STAT kaolin ACT, and Hepcon HMS Plus instruments for correlation and comparison. In the study, several coagulation parameters were assessed using the iCoagLab, including activated clotting time (ACT), clot progression rate/fibrin polymerization (α-angle), and clot strength (MA) and the tool’s capability to monitor anticoagulation during cardiac surgery.
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